Hello Eric,
the ACT100 and ACT200 courses are the two main courses for SAP Activate. While the courses demonstrate the use of SAP Activate on SAP S/4HANA solution the course covers other products as well.
When we considered the course design we made a decision to use SAP S/4HANA as a solution we references when we explain the SAP Activate approach. The content in the journeys explains the similarities and differences for other cloud and on-premise solutions.
Best Regards, Jan